I do not think that if you are irritated by tags it necessarily means that you are autistic. I get irritated by tags and I have been tested for autism and I am not autistic. I am not completely neurotypical in other ways though.

It is impossible to prove that it is the case that everything is fake and it is impossible that it isn’t. Lots of things like this we cannot know for sure. However, you parents being real, society being real etc is a less complex explanation than everything being a VR simulation. If you do not have additional information, then the less complex explanation often is the most likely. So, if you assume reality is not a simulation, you are more likely to be right.