• Assassassin@lemmy.dbzer0.com
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    4 days ago

    I’d expect nothing less from this admin. Really odd that it’s an ingredient banned by the Pentagon rather than like… The FDA? Isn’t kava root in all sorts of supplements already? What’s the pentagon’s reason for throwing their hat in the ring?

      • Assassassin@lemmy.dbzer0.com
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        4 days ago

        The National Toxicology Program (NTP) conducted a comprehensive toxicology rodent study comprising a 2-week, 14-week (3 month), and 2-year toxicity and carcinogenicity studies in F344/N rats and B6C3F1 mice to address kava associated liver toxicity and carcinogenicity concerns. The study revealed clear evidence of carcinogenic activity in male mice with some evidence of carcinogenic activity in female mice, and an equivocal evidence of carcinogenic activity among male rats. In addition, kava extract caused increased incidences of tumor-like lesions in eyes, kidneys, liver, pancreas and forestomach in male and female rats, in the liver of male and female mice, and in the forestomach of female mice. In the two-week studies, rats and mice were administered orally 0, 0.125, 0.25, 0.5, 1 and 2 g/kg/d kava extract by gavage. Kava-induced toxicity was observed in the livers of both rats and mice. Dose dependent increases in the absolute and relative liver weights were observed in the 1.0 g/kg and 2.0 g/kg males and in ≥0.5g/kg in female rats.

        Yup, that’ll do it lol. Thanks for the link. It is a little over my head in places, but very informative.

    • limonfiesta@lemmy.world
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      4 days ago

      Supplement Kava is snake oil.

      Kava tea on the other hand, prepared from ground root, is a legitimate mind altering substance.

      I don’t think it’s nearly as effective as many claim it to be, but it can be pleasant and its effects are real, if limited.

      • prole@lemmy.blahaj.zone
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        3 days ago

        So if they put the material from the tea into a supplement, it nullifies it somehow? Why is it legitimate as a tea but not in a supplement?

        • limonfiesta@lemmy.world
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          3 days ago

          Two problems with Kava supplements, quantity and quality.

          it takes a lot more Kava to feel the effects than can be contained in a capsule, or 5.

          To get around the quantity issue they’ll often use supplement grade kavalactones extracts, which are widely regarded as also ineffective, but it looks good on a packaging label.

          Maybe pharmaceutical grade kavalactone extract would be good in a high dosage, I can’t speak to that, either way, I’m talking about supplements, so I’ll refer you to my original snake oil comment.